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Christian McCaffrey, Justin Jefferson and Mark Andrews are the most expensive players at their respective positions in the Week 1 NFL DFS player pool on DraftKings and FanDuel, with Lamar Jackson the top quarterback on the former and Jalen Hurts on the latter. However, not even the most optimal NFL DFS strategy can fit all of the top players at each position under the NFL DFS salary cap. Decisions will have to be made on who to roster and who to leave out of Week 1 NFL DFS lineups.

McCaffrey was a touchdown machine last year, but faces a Steelers defense that allowed just seven rushing TDs a season ago. That was the fewest in the league and the fewest by any team since 2018. Perhaps this is a week to leave McCaffrey out of your NFL DFS lineups and allot your salary elsewhere. Before setting your NFL DFS lineups for Week 1 on sites like DraftKings and FanDuel, be sure to check out the NFL DFS advice, strategy and stacks from SportsLine daily Fantasy expert Mike McClure

McClure is a legendary professional DFS player with over $2 million in career winnings. He uses a powerful prediction model that simulates every snap of NFL action, taking factors such as matchups, statistical trends and injuries into account. This allows him to find the best DFS values that he shares only with members at SportsLine. His methodology has led to enormous cashes on FanDuel and DraftKings.

He took down two high-stakes tournaments on FanDuel in 2020 and recorded a pair of top-10 finishes in tournaments with over 130,000 entrants on DraftKings. His lineups also finished inside the top 1 percent in more than a dozen other tournaments. Last year, he won the DraftKings Millionaire Maker twice and the FanDuel Million once.

Now, McClure has turned his attention to the Week 1 NFL schedule and locked in his top daily Fantasy football picks. You can only see them by heading to SportsLine.

Top NFL DFS picks for Week 1

One of McClure’s top NFL DFS picks for Week 1 is Vikings receiver Justin Jefferson at $8,800 on DraftKings and $9,500 on FanDuel. Jefferson was at the top of most statistical leaderboards last year, when he led all players in receptions (128) and receiving yards (1,809). Through three seasons, his 96.5 receiving yards per game are the highest in NFL history.

Jefferson posted a 9-184-2 stat line in Week 1 of last season and his opponent this year gives him a shot of matching those totals. Only one team allowed more passing touchdowns than the Buccaneers in 2022, and they return eight starters from that unit. Overall, Tampa allowed the seventh-most Fantasy points to wide receivers a year ago, making this a plus-matchup for an elite receiver.

Part of McClure’s optimal NFL DFS strategy also includes rostering Packers running back Aaron Jones at $6,300 on DraftKings and $7,200 on FanDuel. Jones is coming off a season with over 1,500 total yards and seven touchdowns. He averaged 110 scrimmage yards in two matchups against Week 1 opponent Chicago and also found the endzone twice.

Over his last seven games against the Bears, Jones has scored eight touchdowns and could be featured even more come Sunday than in those previous games. With Green Bay turning the page from Aaron Rodgers to Jordan Love, the team is expected to lean more on its ground game to help out its young quarterback. Jones should also be a frequent target on short passes from Love, and only Austin Ekeler (23) has more touchdown receptions than Jones (16) amongst running backs since 2018. See the rest of McClure’s NFL DFS player pool here.

How to set NFL DFS lineups for Week 1

McClure is also targeting an undervalued player who is set to explode for huge numbers in Week 1. This pick could be the difference between winning your tournaments and cash games or going home with nothing. You can only see who it is here

So who is Mike McClure putting in his optimal NFL DFS lineups for Week 1? Visit SportsLine now to see optimal NFL DFS picks, rankings, advice, and stacks, all from a daily Fantasy expert with more than $2 million in winnings, and find out.



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